Skip to main content
editor@theusajournals.com | Oscar Publishing Services Journal Home
Login

International Journal of Medical Sciences And Clinical Research

Peer Reviewed | Open Access | E-ISSN: 2771-2265
Published Article

Disruption of Oral Ecological Homeostasis Under Chronic Particulate Exposure: Pathobiological Mechanisms and Translational Prevention Strategies

Disruption of Oral Ecological Homeostasis Under Chronic Particulate Exposure: Pathobiological Mechanisms and Translational Prevention Strategies

Authors

  • Sadikova Iroda Erkinovna
    Assistant, Department of Propedeutics of Therapeutic Dentistry, Tashkent State Medical University, Tashkent, Uzbekistan

DOI:

https://doi.org/10.37547/ijmscr/Volume06Issue04-22

Keywords:

Occupational exposure mineral dust oral health

Abstract

Occupational exposure to mineral dust remains a significant yet underexplored determinant of oral health among industrial workers. This narrative review synthesizes current evidence on the impact of airborne particulate matter in stone-processing environments on dental hard tissues, oral mucosa, and periodontal structures. Special emphasis is placed on the interaction between mechanical abrasion, salivary dysfunction, and microbiological imbalance as key drivers of oral pathology [2,3].

Available literature indicates that chronic exposure to silica-containing dust contributes to enamel microdamage, altered salivary composition, and dysbiosis of the oral microbiome. These changes collectively promote the development of non-carious lesions, dentin hypersensitivity, and periodontal inflammation. Additionally, adverse microclimatic conditions—such as elevated temperature and low humidity—further exacerbate salivary hypofunction and compromise oral defense mechanisms.

Preventive strategies are discussed from a multidisciplinary perspective, including engineering controls, personal protective equipment compliance, and clinical interventions. The findings highlight the necessity of integrated occupational and dental health programs aimed at early detection and risk mitigation [1].

References

GBD 2017 Oral Disorders Collaborators. A systematic analysis for the Global Burden of Disease Study 2017 // Journal of Dental Research. — 2020. — Vol. 99, № 4. — P. 362–373. — DOI: 10.1177/0022034520908533. — URL: https://pubmed.ncbi.nlm.nih.gov/32122215/.

Kassebaum N. J., Smith A. G. C., Bernabé E., Fleming T. D., Reynolds A. E., Vos T., Murray C. J. L., Marcenes W. Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990–2015: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors // Journal of Dental Research. — 2017. — Vol. 96, № 4. — P. 380–387. — DOI: 10.1177/0022034517693566. — URL: https://pubmed.ncbi.nlm.nih.gov/28792274/.

Petersen P. E., Ogawa H. The global burden of periodontal disease: towards integration with chronic disease prevention and control // Periodontology 2000. — 2012. — Vol. 60, № 1. — P. 15–39. — DOI: 10.1111/j.1600-0757.2011.00425.x. — URL: https://pubmed.ncbi.nlm.nih.gov/22909104/.

Dawes C., Pedersen A. M. L., Villa A., Ekström J., Proctor G. B., Vissink A., Aframian D., McGowan R., Aliko A., Narayana N., Sia Y. W., Joshi R. K., Jensen S. B., Kerr A. R., Wolff A. The functions of human saliva: a review sponsored by the World Workshop on Oral Medicine VI // Archives of Oral Biology. — 2015. — Vol. 60, № 6. — P. 863–874. — DOI: 10.1016/j.archoralbio.2015.03.004. — URL: https://doi.org/10.1016/j.archoralbio.2015.03.004.

Marsh P. D., Zaura E. Dental biofilm: ecological interactions in health and disease // Journal of Clinical Periodontology. — 2017. — Vol. 44, Suppl. 18. — P. S12–S22. — DOI: 10.1111/jcpe.12679. — URL: https://pubmed.ncbi.nlm.nih.gov/28266111/.

Lussi A., Carvalho T. S. Erosive tooth wear: a multifactorial condition of growing concern and increasing knowledge // Monographs in Oral Science. — 2014. — Vol. 25. — P. 1–15. — DOI: 10.1159/000360380. — URL: https://pubmed.ncbi.nlm.nih.gov/24993253/.

Johansson A. K., Omar R., Carlsson G. E., Johansson A. Dental erosion and its growing importance in clinical practice: from past to present // International Journal of Dentistry. — 2012. — Vol. 2012. — Article ID 632907. — DOI: 10.1155/2012/632907. — URL: https://doi.org/10.1155/2012/632907.

Melguizo-Rodríguez L., Costela-Ruiz V. J., Manzano-Moreno F. J., Ruiz C., Illescas-Montes R. Salivary biomarkers and their application in the diagnosis and monitoring of the most common oral pathologies // International Journal of Molecular Sciences. — 2020. — Vol. 21, № 14. — Article 5173. — DOI: 10.3390/ijms21145173. — URL: https://www.mdpi.com/1422-0067/21/14/5173.

Buzalaf M. A. R., Magalhães A. C., Wiegand A. Alternatives to fluoride in the prevention and treatment of dental erosion // Monographs in Oral Science. — 2014. — Vol. 25. — P. 244–252. — DOI: 10.1159/000360557. — URL: https://pubmed.ncbi.nlm.nih.gov/24993272/.

Al-Kindi S. G., Brook R. D., Biswal S., Rajagopalan S. Environmental determinants of cardiovascular disease: lessons learned from air pollution // Nature Reviews Cardiology. — 2020. — Vol. 17, № 10. — P. 656–672. — DOI: 10.1038/s41569-020-0371-2. — URL: https://pubmed.ncbi.nlm.nih.gov/32382149/.

Brook R. D., Rajagopalan S., Pope C. A. III, Brook J. R., Bhatnagar A., Diez-Roux A. V., Holguin F., Hong Y., Luepker R. V., Mittleman M. A., Peters A., Siscovick D., Smith S. C. Jr., Whitsel L., Kaufman J. D. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association // Circulation. — 2010. — Vol. 121, № 21. — P. 2331–2378. — DOI: 10.1161/CIR.0b013e3181dbece1. — URL: https://pubmed.ncbi.nlm.nih.gov/20458016/.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Silica dust, crystalline, in the form of quartz or cristobalite // IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 100C: Arsenic, Metals, Fibres, and Dusts. — Lyon: International Agency for Research on Cancer, 2012. — P. 355–405. — URL: https://www.ncbi.nlm.nih.gov/books/NBK304375/.

World Health Organization. Hazard prevention and control in the work environment: airborne dust. — Geneva : World Health Organization, 1999. — URL: https://www.who.int/publications/i/item/WHO-SDE-OEH-99-14.

Nanci A., ed. Ten Cate’s Oral Histology: Development, Structure, and Function. — 9th ed. — St. Louis: Elsevier, 2018. — ISBN 978-0-323-48524-1. — URL: https://shop.elsevier.com/books/ten-cates-oral-histology/nanci/978-0-323-48524-1

Scully C. Oral and Maxillofacial Medicine: The Basis of Diagnosis and Treatment. — 3rd ed. — Edinburgh: Elsevier, 2013. — 448 p. — ISBN 978-0-7020-4948-4. — URL: https://shop.elsevier.com/books/oral-and-maxillofacial-medicine/scully/978-0-7020-4948-4.

Genco R. J., Borgnakke W. S. Risk factors for periodontal disease // Periodontology 2000. — 2013. — Vol. 62, № 1. — P. 59–94. — DOI: 10.1111/j.1600-0757.2012.00457.x. — URL: https://pubmed.ncbi.nlm.nih.gov/23574464/.

Zaura E., Nicu E. A., Krom B. P., Keijser B. J. F. Acquiring and maintaining a normal oral microbiome: current perspective // Frontiers in Cellular and Infection Microbiology. — 2014. — Vol. 4. — Article 85. — DOI: 10.3389/fcimb.2014.00085. — URL: https://pubmed.ncbi.nlm.nih.gov/25019064/.

Schwendicke F., Frencken J. E., Bjørndal L., Maltz M., Manton D. J., Ricketts D., Van Landuyt K., Banerjee A., Campus G., Doméjean S., Fontana M., Leal S., Lo E., Machiulskiene V., Schulte A., Splieth C., Zandona A. F., Innes N. P. T. Managing carious lesions: consensus recommendations on carious tissue removal // Advances in Dental Research. — 2016. — Vol. 28, № 2. — P. 58–67. — DOI: 10.1177/0022034516639271. — URL: https://pubmed.ncbi.nlm.nih.gov/27099358/.