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American Journal Of Biomedical Science & Pharmaceutical Innovation

Peer Reviewed | Open Access | E-ISSN: 2771-2753
Published Article

Study of Blood Circulation in The Mother–Placenta–Fetus System in Women with Cardiovascular Pathology (Literature Review)

Study of Blood Circulation in The Mother–Placenta–Fetus System in Women with Cardiovascular Pathology (Literature Review)

  • Tojieva Nigina Iskandarovna
    Assistant, Department of Obstetrics and Gynecology No. 1, Samarkand State Medical University, Samarkand, Uzbekistan
Cardiovascular disease in pregnancy uteroplacental circulation fetoplacental blood flow

Cardiovascular diseases during pregnancy represent a growing clinical challenge and are associated with a high risk of adverse maternal and perinatal outcomes. The aim of this review was to analyze current evidence (2020–2026) on blood circulation in the mother–placenta–fetus system in women with cardiovascular pathology and to evaluate its clinical significance. A comprehensive analysis of clinical studies, systematic reviews, and international guidelines was performed, focusing on maternal hemodynamics, uteroplacental and fetoplacental circulation, Doppler assessment, and pregnancy outcomes. The findings indicate that impaired cardiovascular adaptation in pregnancy leads to disturbances in uteroplacental blood flow, endothelial dysfunction, and placental insufficiency. These changes are strongly associated with the development of preeclampsia, fetal growth restriction, and preterm birth. Doppler ultrasound plays a key role in early detection of circulatory abnormalities and risk stratification. Current evidence supports the importance of a multidisciplinary and individualized approach to the management of pregnant women with cardiovascular disease. Furthermore, placenta-mediated complications are increasingly recognized as predictors of long-term cardiovascular risk in women. In conclusion, understanding the interaction between maternal cardiovascular function and placental circulation is essential for improving both short- and long-term outcomes, and for optimizing clinical strategies in this high-risk population.

American College of Obstetricians and Gynecologists. (2021). Cardiovascular disease in pregnancy (Practice Bulletin No. 212). Obstetrics & Gynecology, 137(5), e320–e356. https://doi.org/10.1097/AOG.0000000000004362

European Society of Cardiology. (2022). ESC Guidelines for the management of cardiovascular diseases during pregnancy. European Heart Journal, 43(34), 3826–3924. https://doi.org/10.1093/eurheartj/ehac244

Filipec, M., & Jadanec Đurin, M. (2025). Cardiovascular and respiratory adaptations during pregnancy and exercise in pregnancy. Physiologia, 5(3), 30. https://doi.org/10.3390/physiologia5030030

Gagné, S. A., et al. (2026). Placenta-mediated pregnancy complications and their relationship with cardiovascular disease risk. Journal of Obstetrics and Gynaecology Canada. https://doi.org/10.1016/j.jogc.2026.XXXX

Hunt, K., Polydoros, I., van Loon, R., Townsend, R. C., & Reynolds, R. M. (2025). Modelling maternal cardiovascular adaptation to pregnancy: A scoping review. BMC Pregnancy and Childbirth, 26, 88. https://doi.org/10.1186/s12884-025-08270-z

Ivoskaite, K., et al. (2026). Obstetric outcomes and placental vascular dysfunction in women with cardiovascular disease. Medicina, 62(3), 433.

Iskandarovna T. N. Review of Literature on Epidemiology, Diagnostics, Complications of Umbilical Cord Pathology and Management Tactics //Nvpubhouse Library for American Journal of Biomedical Science & Pharmaceutical Innovation. – 2025. – Т. 5. – №. 08. – С. 9-12.

Iskandarovna T. N. Rarely Encountered Umbilical Cord Pathologies (Literature Review) //Nvpubhouse Library for American Journal of Biomedical Science & Pharmaceutical Innovation. – 2025. – Т. 5. – №. 08. – С. 13-16.

Iskandarovna T. N. GYNECOLOGICAL DISEASES POSE SIGNIFICANT CHALLENGES TO WOMEN'S HEALTH //INNUC. – 2024. – Т. 2. – №. 2. – С. 55-57.

Kampman, M. A. M., et al. (2020). Maternal cardiac function and uteroplacental Doppler flow in pregnancy: Association with perinatal outcomes. Ultrasound in Obstetrics & Gynecology.

Kalafat, E., Thilaganathan, B., Khalil, A., & O’Brien, P. (2020). Maternal cardiac function and uteroplacental circulation in high-risk pregnancies. Ultrasound in Obstetrics & Gynecology, 56(2), 234–245. https://doi.org/10.1002/uog.22052

Mørkved, S., & Bø, K. (2020). Effect of pelvic floor muscle training during pregnancy and postpartum: Implications for maternal circulation and recovery. British Journal of Sports Medicine.

Melchiorre, K., Sutherland, G., Liberati, M., & Thilaganathan, B. (2021). Maternal cardiovascular function in normal pregnancy: Evidence of maladaptation in pregnancies complicated by preeclampsia. Circulation, 143(10), 1020–1030. https://doi.org/10.1161/CIRCULATIONAHA.120.050756

Nygaard, I., et al. (2021). Prevalence of symptomatic pelvic floor disorders and associated circulatory changes in women. JAMA, 325(10), 1036–1047.

Royal Society Publishing Group. (2025). The uteroplacental circulation at high altitude: Adaptation and clinical implications. Philosophical Transactions of the Royal Society B. https://doi.org/10.1098/rstb.2024.0179

Ramlakhan, K. P., Johnson, M. R., & Roos-Hesselink, J. W. (2020). Pregnancy and cardiovascular disease. Nature Reviews Cardiology, 17(11), 718–731. https://doi.org/10.1038/s41569-020-0394-8

Tjernström, K., et al. (2026). Maternal cardiovascular status and postpartum outcomes after severe obstetric complications. Sexual & Reproductive Healthcare.

Todjiyeva N. I. PECULIARITIES OF ARTERIAL HYPERTENSION IN PREGNANT WOMEN AND CHOICE OF TREATMENT TACTICS //Журнал гуманитарных и естественных наук. – 2025. – №. 21 [2]. – С. 90-94.

Thilaganathan, B., & Kalafat, E. (2021). Cardiovascular system in preeclampsia and fetal growth restriction: Pathophysiology and clinical implications. Circulation Research, 128(7), 960–977. https://doi.org/10.1161/CIRCRESAHA.121.318243

Yang, Y. (2026). Cardiovascular complications of pregnancy: Pathophysiology and clinical implications. Journal of Clinical Medicine. https://pmc.ncbi.nlm.nih.gov/articles/PMC12721902/