Background: The issue of coronary artery disease (CAD) is particularly significant among patients with type 2 diabetes mellitus (T2DM), the prevalence of which is steadily increasing globally. While coronary artery bypass grafting (CABG) is proven effective, the presence of T2DM significantly affects perioperative risks and long-term outcomes of the procedure.

Objective: To conduct a comparative analysis of demographic, clinical, surgical parameters, and postoperative complications in patients with CAD depending on the presence or absence of T2DM.

Materials and Methods: Data from 384 patients who underwent elective CABG were analyzed. Patients were divided into two groups: 125 patients with T2DM (Group 1) and 259 patients without diabetes (Group 2). Data analysis was performed using nonparametric methods in SPSS 26.0 and R 4.0.2, with statistical significance set at p ≤ 0.05.

Results: A higher proportion of women (30.4%) and pronounced comorbidity were observed in patients with T2DM. The incidence of acute myocardial infarction (AMI) and effort angina was comparable in both groups, but postinfarction cardiosclerosis (PICS) and chronic heart failure (CHF) were more prevalent in patients with T2DM. Early postoperative complications (arrhythmias, acute cardiovascular insufficiency, stroke) were statistically significantly more frequent in patients with T2DM, while hospital mortality did not differ: 4.8% in patients with T2DM and 3.8% in those without diabetes. Surgical characteristics, including the use of cardiopulmonary bypass (CPB) and the number of grafts, showed minimal differences between groups, indicating a standardized approach to CABG regardless of T2DM status.

Conclusions: The presence of T2DM in patients with CAD significantly affects the frequency of early postoperative complications but does not impact hospital mortality after CABG, suggesting an increased risk of adverse outcomes.

Applications: To develop strategies for optimizing the treatment of patients with T2DM undergoing CABG, considering their elevated risk of complications.

Coronary artery bypass grafting, type 2 diabetes mellitus, coronary artery disease

World Health Organization. Cardiovascular diseases (CVDs). Fact sheet. Geneva: WHO; 2021. Available from: [URL]

Roth GA, Mensah GA, Johnson CO, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study. J Am Coll Cardiol. 2020;76(25):2982–3021. doi: 10.1016/j.jacc.2020.11.010

International Diabetes Federation. IDF Diabetes Atlas, 10th edn. Brussels: IDF; 2021. Available from: [URL]

Sulimov VA, Moiseev VS. Diabetes mellitus and cardiovascular diseases. Kardiologiia. 2021;59(4):5–14. doi: 10.18087/cardio.2021.4.10225

Dedov II, Shestakova MV, Mayorov AYu, et al. Algorithms for specialized medical care for patients with diabetes mellitus. Sakharnyi Diabet. 2021;24(1S):1–148. doi: 10.14341/DM12802

Bokeria LA, Gudkova RG. Cardiovascular surgery – 2020. Diseases and congenital anomalies of the circulatory system. Moscow: A.N. Bakulev National Medical Research Center for Cardiovascular Surgery; 2021. 208 p.

Bokeria OL, Buziasvili YuI, Klyuchnikov IV, et al. Coronary artery bypass grafting in patients with coronary artery disease and concomitant diabetes mellitus. Annaly Khirurgii. 2020;25(3):135–142. doi: 10.24022/1560-9502-2020-25-3-135-142

Shalimov SA, Dronov AI, Kondratenko PG. Surgery of diabetes mellitus. Kyiv: Zdorov’ya; 2020. 392 p.

Akchurin RS, Shiryaev AA, Vasiliev VP, et al. Results of surgical treatment of CAD in patients with type 2 diabetes mellitus. Kardiologiia i Serdechno-Sosudistaya Khirurgiya. 2021;12(4):286–291. doi: 10.17116/kardio202112041286

Komarov RN, Shneider YuA, Karaskov AM, et al. Impact of diabetes mellitus on coronary artery bypass grafting outcomes. Patologiya Krovoobrashcheniya i Kardiokhirurgiya. 2020;24(2):17–25. doi: 10.21688/1681-3472-2020-2-17-25

Chen Y, Wang L, Zhang M, et al. Diabetes mellitus and long-term outcomes after coronary artery bypass grafting: A systematic review and meta-analysis. Heart Vessels. 2021;36(8):1234–1245. doi: 10.1007/s00380-021-01825-4

Rodriguez-Granillo GA, Campuzano R, Mrad G, et al. Impact of diabetes on cardiovascular outcomes in patients undergoing coronary artery bypass grafting. Curr Diabetes Rev. 2020;16(7):742–750. doi: 10.2174/1573399815666190708102345

Smith PK, Califf RM, Tuttle RH, et al. Selection of surgical or percutaneous coronary intervention provides differential longevity benefit. Ann Thorac Surg. 2021;111(4):1198–1205. doi: 10.1016/j.athoracsur.2020.09.032

Liu Y, Bai F, Tang Z, et al. Perioperative risk factors for diabetic patients undergoing coronary artery bypass grafting. J Thorac Dis. 2020;12(10):5930–5939. doi: 10.21037/jtd-20-1844

Wang J, Chen H, Li X, et al. Diabetes mellitus and postoperative complications after coronary artery bypass grafting: A propensity-matched analysis. J Cardiothorac Surg. 2021;16(1):145. doi: 10.1186/s13019-021-01525-8

Martinez-Lopez D, Cediel G, Moral S, et al. Impact of diabetes on long-term mortality after coronary artery bypass grafting. Rev Esp Cardiol. 2020;73(8):635–642. doi: 10.1016/j.rec.2019.09.015

Thompson A, Patel D, Nolan J, et al. Diabetes and coronary artery bypass grafting: Current perspectives and future directions. Diabetes Metab Res Rev. 2021;37(2):e3381. doi: 10.1002/dmrr.3381

Kim JS, Park KH, Lee JH, et al. Glycemic control and outcomes in diabetic patients undergoing coronary artery bypass grafting. Korean J Thorac Cardiovasc Surg. 2020;53(4):198–205. doi: 10.5090/kjtcs.2020.53.4.198

Singh M, Rihal CS, Gersh BJ, et al. Twenty-five-year trends in in-hospital and long-term outcomes of percutaneous coronary intervention and coronary artery bypass grafting for patients with diabetes. Circulation. 2021;143(12):1208–1218. doi: 10.1161/CIRCULATIONAHA.120.050774

Uzbekistan: Country profile on noncommunicable diseases, 2020. Geneva: World Health Organization; 2020. Available from: https://www.who.int/nmh/countries/uzb_en.pdf