Articles
| Open Access |
https://doi.org/10.37547/ajbspi/Volume05Issue11-08
Multiparametric Ultrasound Assessment Of Non-Alcoholic Fatty Liver Disease Using Modern Techniques And Evaluation Of Clinical Significance
Abstract
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver damage. Ultrasound and elastography play a key role in the early detection of steatosis and fibrosis, allowing for an objective assessment of the liver's morphofunctional state without invasive procedures. The work presents the characteristics of the main ultrasound signs of NAFLD, the possibility of quantitative assessment of steatosis, as well as the role of compression and shift wave elastography in determining the degree of fibrosis. Current diagnostic criteria, correlation of ultrasound parameters with clinical and biochemical parameters, and modern requirements for disease progression risk stratification are considered. The use of a comprehensive ultrasound approach allows for increased accuracy in diagnosing NAFLD and determining the optimal management tactics for patients.
Keywords
NAFLD, ultrasound diagnostics, elastography, steatosis
References
Chalasani N., Younossi Z., Lavine J. E., et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328–357.
European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol. 2021;75(3):659–689.
Younossi Z., Koenig A., Abdelatif D., et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2019;64(1):73–84.
Rinella M. E. Nonalcoholic fatty liver disease: A systematic review. JAMA. 2015;313(22):2263–2273.
Wong V. W., Adams L. A., de Lédinghen V., Wong G. L., Sookoian S. Noninvasive biomarkers in NAFLD and NASH—Current progress and future promise. Nat Rev Gastroenterol Hepatol. 2018;15(8):461–478.
Petta S., Wong V. W., Cammà C., et al. Improved noninvasive prediction of liver fibrosis by combining transient elastography and serum biomarkers. Expert Rev Gastroenterol Hepatol. 2017;11(7):641–649.
Cassinotto C., Boursier J., de Lédinghen V., et al. Liver stiffness measurement by transient elastography improves detection of liver fibrosis in patients with NAFLD. Hepatology. 2016;63(5):1817–1827.
Ferraioli G., Wong V. W., Castera L., et al. Liver ultrasound elastography: An update from the World Federation for Ultrasound in Medicine and Biology. Ultrasound Med Biol. 2018;44(12):2419–2440.
Karlas T., Petroff D., Sasso M., et al. Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis. J Hepatol. 2017;66(5):1022–1030.
Dietrich C. F., Bamber J., Berzigotti A., et al. EFSUMB Guidelines and Recommendations on the clinical use of liver ultrasound elastography, Update 2017. Ultraschall in der Medizin. 2017;38(04):377–394.
Castera L. Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease. Gastroenterology. 2017;152(8):1760–1775.
Ballester M. P., Monfort D., Alberich-Bayarri A., et al. Quantitative ultrasound-based imaging techniques in NAFLD. Diagnostics. 2021;11(6):977.
Singh S., Muir A. J., Dieterich D. T., Falck-Ytter Y. AGA Technical review on the role of elastography in evaluating liver fibrosis. Gastroenterology. 2017;152(6):1544–1577.
Сайфутдинов Р. Г., Иванов А. Ю. Неалкогольная жировая болезнь печени: современные подходы к диагностике. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2020;30(2):32–39.
Олейник Е. В., Маев И. В., Самсонов А. А. Ранняя диагностика и клиническое значение НАЖБП. Клиническая медицина. 2019;97(4):280–287.
Багдасарян А. С., Колесникова О. П. Возможности ультразвуковой эластографии в диагностике заболеваний печени. Ультразвуковая и функциональная диагностика. 2019;2:22–33.
Ботвиньев О. К., Кузнецов Н. С. Диагностика стеатоза печени: современные возможности ультразвуковых методов. Вестник современной клинической медицины. 2021;14(1):45–52.
Попов Е. Н., Романюк А. М. Метаболические факторы и прогрессирование неалкогольной жировой болезни печени. Терапевтический архив. 2019;91(9):74–80.
Article Statistics
Copyright License
Copyright (c) 2025 Gulnora Akmalovna Yusupalieva, Abzalova Munisa Yakupdjanovna, Talipova Sevara Makhmudjonovna
This work is licensed under a Creative Commons Attribution 4.0 International License.