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American Journal Of Biomedical Science & Pharmaceutical Innovation

Peer Reviewed | Open Access | E-ISSN: 2771-2753
Published Article

Development Of An Effective Technology For Extraction Of Cholegeric Collection From Local Medicinal Plant Raw Materials

Development Of An Effective Technology For Extraction Of Cholegeric Collection From Local Medicinal Plant Raw Materials

Authors

  • M.Zh.Khudoiberdieva
    Applicant of the Tashkent Scientific Research Institute, vaccines and serums, Tashkent, Uzbekistan
  • ZN Eshmuratov
    Research Institute of Oriental Medicine, Tashkent, Uzbekistan
  • HM Kamilov
    Doctor of Pharmaceutical Sciences, Professor, Tashkent State Medical University, Tashkent, Uzbekistan

DOI:

https://doi.org/10.37547/ajbspi/Volume06Issue01-02

Keywords:

Choleretic collection flavonoids extractive substances

Abstract

This paper presents the development of a technology for the aqueous-alcoholic extraction of biologically active substances from a multi-component choleretic herbal collection consisting of calendula officinalis (Calendula officinalis), flowers of common tansy ( Tanacetum vulgare ) and peppermint leaves ( Mentha piperita). The following quantitative indicators were chosen as criteria for the process efficiency: the sum of flavonoids (calculated as rutin) and the content of extractive substances.

A series of laboratory experiments was conducted with varying parameters: ethanol concentration (20–70%), temperature (20–80 ° C), stirring speed (40–160 rpm), and extraction time (15–90 min). Extraction efficiency was found to be most significantly influenced by extractant concentration and temperature. Optimal values for these factors were determined. The maximum yield of total flavonoids and extractive substances was achieved under these conditions, amounting to approximately 92.3% for total flavonoids and 91.7% for extractive substances of the maximum possible values. The obtained results confirm the scientific validity and practical applicability of the proposed technology.

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