Articles
| Open Access |
https://doi.org/10.37547/ajbspi/Volume05Issue09-06
Biochemical And Morphological Changes In The Blood And Pancreas Of Rats With Alloxan Diabetes
Abstract
The morphological effect of alloxan on the pancreas is fundamental for modeling diabetes in experimental medicine. Alloxan is a toxic substance that has a specific effect on pancreatic cells, especially on the beta cells of the islets of Langerhans, which are responsible for insulin production. Morphological changes in the pancreas of rats injected with alloxan tetrahydrate solution confirm the formation of diabetes in the animal's body. In addition, changes in biochemical parameters in the blood indicate the development of hyperglycemia. These processes indicate that a model of diabetes under the influence of alloxan has been successfully induced in the body of rats.
Keywords
Hypoglycemia, Langerhans, alloxan
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