Skin stem cells play a key role in maintaining homeostasis and regeneration of the epidermis, ensuring continuous renewal of the skin and restoration of damaged areas. The article discusses modern concepts of the morphological and functional features of skin stem cell niches, as well as the mechanisms of their activation and differentiation. The latest research aimed at using these cells in tissue engineering and transplantation technologies, which open up new prospects for the treatment of skin diseases and injuries, is highlighted. Particular attention is paid to biomedical approaches to managing regenerative processes using stem cells to improve the effectiveness of therapy and create artificial skin substitutes.

Skin stem cells, epidermis, regeneration

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