Articles
| Open Access |
https://doi.org/10.37547/ajbspi/Volume05Issue06-06
Blood-Brain Barrier: Structure, Function and Neurological Consequences Of Disruption: Role In Brain Protection And Maintenance Of Homeostasis. Disturbances In Strokes, Neuroinfections , Neurodegeneration , Tumors
Abstract
The blood-brain barrier (BBB) is a complex morphofunctional system that ensures selective permeability between the bloodstream and tissues of the central nervous system. This article discusses the anatomical and histological structure of the BBB, its key functions in protecting the brain and maintaining neuronal homeostasis. Particular attention is paid to the mechanisms of barrier function impairment in various pathological conditions - strokes, neuroinfections , neurodegenerative diseases and brain tumors. The consequences of BBB dysfunction and modern approaches to diagnostics and therapy, including pharmacological modulation and targeted drug delivery technologies are analyzed. The presented material emphasizes the importance of maintaining the integrity of the BBB for neuroprotection and treatment of a wide range of neurological disorders.
Keywords
Blood-brain barrier, neurohomeostasis, permeability
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