In the occurrence and progression of chronic heart failure (CHF), the role of pro- inflammatory cytokines has been established: tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), which induce the synthesis of C-reactive protein (CRP), an increasing the level of these markers leads to the progression of CHF. It was determined that with the development of the maladaptive phase of left ventricular remodeling, there is a sharp rise in the level of pro- inflammatory cytokines and serum CRP, which are closely interrelated with the structural and functional changes of the left ventricle in CHF. Against the background of taking rosuvastatin at a daily dose of 20 mg, there is a decrease in the levels of pro-inflammatory cytokines and serum CRP and a positive dynamics of heart remodeling indicators.

Systemic inflammation, left ventricular remodeling, rosuvastatin

Berezikova Ye.N., Shilova S.N., Yefremov

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