This study presents the development and evaluation of a novel nanoparticle-based topical gel containing the antifungal drug fluconazole. The formulation was designed to enhance drug delivery and efficacy in the treatment of fungal infections. The nanoparticles serve as carriers for fluconazole, facilitating its targeted delivery to the site of infection while minimizing systemic side effects. The topical gel was characterized for its physicochemical properties, drug release profile, and antifungal activity. In vitro and in vivo evaluations demonstrated the effectiveness of the nanoformulation in inhibiting fungal growth and promoting healing. The results suggest that the nanoparticle-based topical gel holds promise as a promising antifungal treatment with potential clinical applications.

Nanoformulation, Topical gel, Fluconazole

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