The article under discussion depicts human papillomaviruses, their relevance and treatment methods. The author of the article considers that one of the urgent problems of modern medicine - papillomavirus infection occupies the first place among sexually transmitted infections in terms of prevalence. HPV causes a wide range of cancers of the reproductive system, including cervical, vulvar, and vaginal cancers, as well as anal canal cancer and anogenital condylomas, which occur in both men and women. One of the reliable method of preventing papillomavirus infection is vaccination. Thanks to the effects of vaccination, it is possible to prevent the development of cancer in 90 to 95% of cases.