Previous research has investigated the technological properties of the dexketoprofen trametamol substance and has been shown to be negative. For this reason, the article covers research on the selection, technology development of a complex of various auxiliary substances for the development of a capsule drug form based on the substance dexketoprofen trametamol. In it, the size of the capsule was determined on scientific basis, based on the scattering density of the substance, and encapsulated masses were prepared using various excipients. As a result of determining the technological properties of these compositions as well as the quality indicators of the capsules obtained, the optimal composition was selected and the capsule technology was developed, in which the dexketoprofen trametamol substance was stored.

substance, capsule, technology

Koroleva I.A. Dexketoprofen – an additional ability to control chronic pain syndrome //Medical Council.-2019.-No. 10.-pp.172-178.

Trukhan D.I., Bagisheva N.V., Goloshubina V.V., Konshu N.V. The possibilities of dexketoprofen in the treatment of pain syndrome at the stage of primary health care //Medical Sciences.-2017.-No. 5.-pp.263-266.

Krasnyuk I.I., Tarasov V.V., Kozlova Zh.M. Studying the influence of technological parameters of the mass production process for encapsulation with tritican – alpha //Medical and pharmaceutical journal “Pulse".-2019. No.10.-pp.131-137.

Yunusova X.M., Jaloliddinova M.Sh. research on the development of the dicomz capsule technology // Journal of Pharmaceutics.-2018. №4.- S.53-55.

F.X.Maksudova., M.B.Baratova., D. Sh.Tadjibaeva. improving the composition and technology of the Xind jenshen capsule// Farmasevticheskiy magazine.- Organizational.-2021.-№1.- S.74-78.

Usmanova M.K., Maksudova F.X., Karimov O.U. Study of structural-mechanical and technological properties of dexketoprofen substance // Pharmaceutical Journal.- Organizational.-2022-№5.- B.31-35.

M.K.Usmanova., F.X.Maksudova. Comparative transformation of technological properties of dexketoprofen trometamol substance and encapsulated massapipd// "current state of the pharmaceutical field: attitudes and perspectives" (international scientific and practical conference, Tashkent, 2023-B.64-65.

Maksudova F.H., Karieva E.S. On the issue of the development of intestinal soluble capsules of nonsteroidal anti-inflammatory action// Farmatsevtika jurnali.-2014.-No.4.-pp.84-89.

State Pharmacopoeia Of The Republic Of Uzbekistan. Toskent -2021. Volume 1, part 1-2.

State Pharmacopoeia of the Russian Federation, XIV ed., Moscow (2018); [Electronic resource], URL: https://femb.ru/record/pharmacopea14.