This comprehensive review delves into the cutting-edge advancements in the treatment landscape of advanced ovarian cancer, with a specific focus on the programmed cell death protein 1 (PD-1) and its ligand PD-L1 pathway. Ovarian cancer, often diagnosed at advanced stages, poses significant challenges due to limited effective treatment options. The emergence of immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway has sparked new hope for improved outcomes. This review explores the mechanistic basis of PD-1/PD-L1 interactions, outlines the evolving clinical trials assessing immune checkpoint inhibitors, and discusses the clinical significance of these therapies in reshaping the therapeutic paradigm for advanced ovarian cancer.

Advanced ovarian cancer, immune checkpoint inhibitors, programmed cell death protein 1

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