Content Analysis of Iodine-Containing Drugs in The Republic of Uzbekistan in 2021-2026 | American Journal Of Biomedical Science & Pharmaceutical Innovation

Authors

Sarvar Aliev

PhD in Pharmacy, Associate Professor of the Department of Pharmacology, Tashkent State Medical University, Tashkent, Uzbekistan

https://orcid.org/0009-0002-4831-807X

DOI:

https://doi.org/10.37547/ajbspi/Volume06Issue05-13

Keywords:

Iodine deficiency diseases content analysis completeness

Abstract

Objective: To evaluate the assortment structure and market dynamics of iodine-containing medicines available on the pharmaceutical market of the Republic of Uzbekistan between 2021 and 2026.

Methods: The study analyzed six consecutive editions of the State Register of Medicines of Uzbekistan using comparative, documentary, content, and mathematical-statistical methods with consideration of dosage forms, international nonproprietary names (INNs), manufacturers, and assortment indicators.

Result: The analysis identified a relatively limited assortment represented by two INNs (potassium iodide and iodine β-cyclodextrin), 28 fixed combinations with folic acid, vitamins, and minerals, 39 trade names, and 50 medicinal products. The renewal index decreased from 0.18 in 2021 to 0.04 in 2026, while the number of discontinued products exceeded the number of newly registered medicines in several years, indicating market consolidation and limited introduction of innovative iodine-containing products.

Conclusion: The findings highlight the necessity of expanding the assortment of iodine-containing medicines, particularly specialized products for children and pregnant women, as well as supporting sustainable market development through improved registration policies and stimulation of local pharmaceutical productio.

References

Duran-Aguero S. and Daga R. Iodine intake in adults: Sociodemographic and dietary determinants from a National Health survey. Clin Nutr ESPEN, 2026. 73: p. 103-124. doi: 10.1016/j.clnesp.2026.103124.

WHO. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 2007. https://www.who.int/publications/i/item/9789241595827

Abdulkhabirova F.M. et al. Clinical practice guidelines “Management of iodine deficiency disorders”. Probl Endokrinol (Mosk), 2021. 67(3): p. 10-25. doi: 10.14341/probl12750.

Patriota E.S.O. et al. Prevalence of insufficient iodine intake in pregnancy worldwide: a systematic review and meta-analysis. Eur J Clin Nutr, 2022. 76(5): p. 703-715. doi: 10.1038/s41430-021-01006-0.

Hollowell J.G. and Haddow J.E. The prevalence of iodine deficiency in women of reproductive age in the United States of America. Public Health Nutr, 2007. 10(12A): p. 1532-1539. doi: 10.1017/S1368980007360862.

Wallborn T. et al. Spot urine iodine levels below the WHO recommendation are not related to impaired thyroid function in healthy children and adolescents. Eur J Nutr, 2021. 60(1): p. 493-502. doi: 10.1007/s00394-020-02268-3.

Kim H.I. et al. Urinary iodine concentration and thyroid hormones: Korea National Health and Nutrition Examination Survey 2013-2015. Eur J Nutr, 2019. 58(1): p. 233-240. doi: 10.1007/s00394-017-1587-8.

Liu T. et al. The Characteristics of Iodine Nutrition Status in China After 20 Years of Universal Salt Iodization: An Epidemiology Study Covering 31 Provinces. Thyroid, 2021. 31(12): p. 1858-1867. doi: 10.1089/thy.2021.0301.

Pang P. et al. A Cross-Sectional Study of Iodine Nutritional Status Among School-Age Children in Chongqing, China. Nutrients, 2025. 17(5). doi: 10.3390/nu17050817.

Wu H. et al. Does the island area also need to insist on salt iodization to prevent iodine deficiency disorders? a cross-sectional survey in Hainan Province, China. Front Endocrinol (Lausanne), 2025. 16: p. 1-9. doi: 10.3389/fendo.2025.1536506.

Qazi T.B. et al. Burden of Goitre and Urinary Iodine Status among Primary School Children in Kashmir, India-Evidence from a Population-Based Iodine Deficiency Disorder Survey. Indian J Endocrinol Metab, 2024. 28(2): p. 177-183. doi: 10.4103/ijem.ijem_40_23.

Ayoub S. et al. Assessment of goiter and iodine deficiency among school children in North Kashmir: A cross-sectional study. J Family Med Prim Care, 2025. 14(2): p. 713-719. doi: 10.4103/jfmpc.jfmpc_1404_24.

Korobitsyna R. et al. Iodine Status of Women and Infants in Russia: A Systematic Review. Int J Environ Res Public Health, 2020. 17(22). doi: 10.3390/ijerph17228346.

Troshina E.A. et al. The problem of iodine deficiency in the Chechen republic: assessment of the current state and ways of solution. Probl Endokrinol (Mosk), 2023. 69(4): p. 38-49. Russian. doi: 10.14341/probl13306.

Businge C.B. et al. The prevalence of insufficient iodine intake in pregnancy in Africa: a systematic review and meta-analysis. Syst Rev, 2022. 11(1): p. 231. doi: 10.1186/s13643-022-02072-6.

Abdalla A.E. et al. Prevalence and determinants of goitre among children of South Kordofan state, Sudan, 2021: an urgent need for effective implementation of universal salt iodisation. Public Health Nutr, 2023. 27(1): p. e18. doi: 10.1017/S1368980023002744.

Law of the Republic of Uzbekistan No. ZRU-97 “On the Prevention of Iodine Deficiency Disorders” dated 03.05.2007. Collection of Legislation of the Republic of Uzbekistan, 2007, No. 17-18, Art. 175; 2015, No. 23, Art. 301; National Legislation Database, 04.11.2022, No. 03/22/800/0990; 21.01.2023, No. 03/23/815/0044. https://lex.uz/docs/1184051#

Ismailov S.I., Rashitov M.M. Progress in the field of prevention of iodine deficiency diseases in the Republic of Uzbekistan (1998–2016). Clinical and experimental thyroidology. 2016;12(3):20–24. https://doi.org/10.14341/ket2016320-24.

WHO. STUDY-GROUP on endemic goitre; final report. Bull World Health Organization, 1953. 9(2): p. 293-301; French transl, 302-9.

Sun D. et al. Eliminating Iodine Deficiency in China: Achievements, Challenges and Global Implications. Nutrients, 2017. 9(4). doi: 10.3390/nu9040361.

Pretell E.A. et al. Elimination of iodine deficiency disorders from the Americas: a public health triumph. Lancet Diabetes Endocrinol, 2017. 5(6): p. 412-414. doi: 10.1016/S2213-8587(17)30034-7.

Liu P. et al. Prevention and Control of Iodine Deficiency Disorders - China, 1995-2020. China CDC Wkly, 2020. 2(20): p. 345-349. doi: 10.46234/ccdcw2020.090.

Grossklaus, R., et al., Iodine Supplementation Before, During and After Pregnancy. Geburtshilfe Frauenheilkd, 2026. 86(3): p. 257-272.

Sunnatov Sh. Kh., Aliev S. U., Zainutdinov Kh. S. Content analysis of the range of drugs used in iodine deficiency diseases // International Academic Bulletin. - 2020. - No. 4. - P. 79-81.

Aliev S. U., Zainutdinov H. S. Analysis of the market of iodine-containing drugs used in endemic goiter // Pharmaceutical journal. - 2008. - No. 4. - P. 4.

State Register of Medicines and Medical Devices. URL: https://www.uzpharm-control.uz/ru/pages/state-register-of-medicines-and-medical-products. accessed: 24.04.2026.

Krawczyk, P. and L. Swiecicki, ICD-11 vs. ICD-10 - a review of updates and novelties introduced in the latest version of the WHO International Classification of Diseases. Psychiatr Pol, 2020. 54(1): p. 7-20. doi: 10.12740/PP/103876.

National Clinical Protocols and Standards in Endocrinology. Turakulov Scientific and Practical Medical Center of Endocrinology, 2025. URL: https://gov.uz/ru/ssv/sections/endkrinolgiya-bolalar-endokrinologiyasi accessed: 24.04.2026.

Aliev, S. [Assortment analysis of iodine-containing medicines registered in the Republic of Uzbekistan for 2021-2026.] (2026). European Journal of Interdisciplinary Research and Development, 51, 205-218. [in Russian] https://ejird.journalspark.org/index.php/ejird/article/view/2090

Dremova, N.B., Medical and Pharmaceutical Commodity Science. 2005, Russia: Kursk Publishing House. 520 p.

Pretell E.A. and Pearce E.N. A History of the Elimination of Iodine Deficiency Disorders in the Americas: A Dramatic Achievement and Lessons Learned. J Nutr, 2024. 154(12): p. 3856-3867. doi: 10.1016/j.tjnut.2024.10.009.