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American Journal Of Biomedical Science & Pharmaceutical Innovation

Peer Reviewed | Open Access | E-ISSN: 2771-2753
Published Article

Comparative Characteristics of The Prevalence of Respiratory Allergy Symptoms in Children of Two Age Groups According to The ISAAC Questionnaire Program

Comparative Characteristics of The Prevalence of Respiratory Allergy Symptoms in Children of Two Age Groups According to The ISAAC Questionnaire Program

Authors

  • Sh.T. Iskandarov
    State Health Insurance Fund of the Republic of Uzbekistan Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan
  • A.A. Ismailova
    Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan
  • G.S. Djambekova
    International Center of Molecular Allergology of the Ministry of Innovative Development of the Republic of Uzbekistan

DOI:

https://doi.org/10.37547/ajbspi/Volume06Issue05-05

Keywords:

Bronchial asthma allergic rhinitis respiratory allergy ISAAC questionnaire

Abstract

Objective. To study the prevalence of bronchial asthma and allergic rhinitis symptoms among schoolchildren using the standardized ISAAC questionnaire and to determine the regional characteristics of the molecular sensitization profile in children with respiratory allergies in the Syrdarya region.

Materials and methods. The study included 6,521 schoolchildren from two age groups. Clinical symptoms of respiratory allergy were assessed among children aged 7–8 years and 13–14 years using the standardized ISAAC questionnaire. The study employed questionnaire-based, clinical, laboratory, serological, molecular, immunological, and statistical research methods. All collected data were entered into Microsoft Excel, processed statistically, and presented in the form of diagrams and tables.

Results. The study demonstrated a high prevalence of respiratory allergy symptoms among schoolchildren in both age groups, with a higher frequency observed in children aged 13–14 years. Comparative analysis with previously published data revealed an increasing trend in the prevalence of bronchial asthma and allergic rhinitis. Early detection of sensitization allows timely implementation of secondary and tertiary prevention strategies for asthma and contributes to the development of personalized treatment approaches aimed at achieving complete disease control. For the first time, molecular sensitization screening using the ALEX multiplex platform was performed among children of two age groups in the Syrdarya region. The obtained findings contribute to the molecular characterization of respiratory allergies and provide a basis for further research and preventive measures.

Conclusions. Standardized epidemiological studies conducted using the ISAAC questionnaire indicate a high prevalence of allergic diseases among schoolchildren and a tendency toward increasing respiratory allergy symptoms with age. The growing prevalence of asthma is associated with more severe disease progression, increased morbidity, and higher healthcare burden. Climatic, geographical, environmental, and genetic factors may contribute to the increasing prevalence of respiratory allergic diseases. Improvement of diagnostic quality and early detection will promote timely treatment and prevention of bronchial asthma in children, reducing complications, disability, and healthcare costs.

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