This study evaluated the relationship between coronary artery calcium (CAC) score and the severity of coronary artery disease in 105 patients with obesity using multislice CT angiography. Calcification was detected in 92.4% of cases and was more frequent in men. Higher CAC scores were strongly associated with multiple and severe coronary stenoses. Despite limited sex and age differences, CAC scoring proved valuable for cardiovascular risk stratification and guiding further diagnostic and therapeutic strategies.
Coronary Artery Calcium Score and Severity of Ischemic Heart Disease in Obesity
DOI:
Keywords:
Abstract
References
Agatston AS, et al. Quantification of coronary artery calcium using ultrafast CT. J Am Coll Cardiol. 1990.
Al Hennawi H, et al. Impact of coronary artery calcium scores on cardiovascular risk. 2025.
Atherosclerosis evaluation and cardiovascular risk estimation using coronary CT angiography. 2024. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11129796/
Ayoub C, et al. Computed tomography evaluation of coronary atherosclerosis. Diagnostics. 2024;14(18):2096.
Budoff MJ, et al. Coronary artery calcium scoring: past, present, and future. JACC Cardiovasc Imaging. 2021.
Criqui MH, et al. Calcium density and cardiovascular risk. JAMA Cardiol. 2020.
Danad I, et al. Diagnostic performance of cardiac imaging methods for CAD. J Am Coll Cardiol. 2021.
Dehghan M, et al. Associations of fats and carbohydrate intake with cardiovascular disease and mortality (PURE study). Lancet. 2020.
DISCHARGE Trial Investigators. Coronary artery calcium score predicts major adverse cardiovascular events. 2024.
Ehara S, et al. Spotty calcification and plaque vulnerability. Circulation. 2020.
Gómez-Díaz D, et al. Role of coronary artery calcium score CT in risk stratification. Diagnostics. 2025;12(11):442.
Hutcheson JD, et al. Mechanisms of vascular calcification. Nat Rev Cardiol. 2020.
Knuuti J, et al. 2020 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020.
Lee SE, et al. Coronary artery calcium and cardiovascular risk in Asian populations. Circulation. 2022.
Mach F, et al. 2020 ESC Guidelines for the management of dyslipidaemias. Eur Heart J. 2020.
McClelland RL, et al. 10-year coronary heart disease risk prediction using CAC (MESA update). J Am Coll Cardiol. 2021.
Motoyama S, et al. Coronary plaque characteristics and risk of acute coronary events. J Am Coll Cardiol. 2020.
Nordestgaard BG, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated. Eur Heart J. 2020.
Otsuka F, et al. The role of microcalcification in plaque vulnerability. J Am Coll Cardiol. 2020.
Tada H, et al. Coronary artery calcium among patients with heterozygous familial hypercholesterolaemia. 2023. Available from: https://pubmed.ncbi.nlm.nih.gov/37193254/