In the article formation of aminoalcohols and aminocompounds by Mannich reaction from acetylenic alcohols and phenylacetylene and also biological activity of halogenated derivatives of the synthesized aminocompounds have been inves -tigated. Acetylenic alcohols were synthesized by the reaction A.E. Favorsky and phenylacetylene was obtained from styrene. The influence of various factors (tem -perature, catalyst, time and nature of solvents) on the yield of aminoalcohols was studied. A theoretical analysis of the mechanism of formation of acetylenic amino- alcohols is given. The physico-chemical properties of the synthesized aminoalcohols and their yields were determined. The chemical structure of aminoalcohols has been confirmed by IR and PMR spectrums. The biological activity of compounds syn-thesized by chlorination and bromination of aminocompounds has been investigated.

Catalyst, Mannich reaction, N-hydroxymethylamine

Neiland O.Ya. Organic chemistry, -M., Higher school, 1990, - 750 p.

Semenov T.A., and Leites I.L. Purification of process gases, -M., 1977.- P. 488

Ogorodnikova S.K. Handbook of petrochemist, Vol. 2 -L.,1978 .--592 -P. 4. [4]. Herbicidal activity of derivatives of acetylenic alcohols Sirlibaev T.S., Kurbanov A.I., Turgunov E., Kultaev K.K., Koblov R.K., Khikmatov A. Agrochemistry. 1985. - No.11, -P. 105-107

Biological activity of some acetylenic aminoalcohols and halogen-containing products based on them Kurbanov A.K., Sirlibaev T.S., Turgunov E., Kultaev K.K., Kovlov R.K, Tarikov S. Agrochemistry, 1986 , - No. 4 -P. 86 -89.

Sirlibaev T.S., Kultaev K.K., Kurbanov A.I. Investigation of the antimicrobel activity of some acetylenic compounds and products obtained on their base. Dep. in Uz NIINTI. - 1989. - № 957 - Uz 89. - 8 p.

Kurbanov A.I. Syntheses based on secondary, tertiary acetylenic alcohols and pyridylacetylenes, possible fields of application of the obtained compounds: dis ... doc. Chem. Sciences. –T., 1998. -FROM. 270 -275.

Kultaev K.K., Turgunov E. An obtaine of singleatomic uncertain alcohols on the base of acethylene and phenyl acethylene and their bromination. Actual problems of modern science, education and training, Urgenhc, 2020, -No. 4.- P. 280-290.

Weigand-Khilgetag. Experimental methods in organic chemistry, -M. Chemistry. 1968. - 944 p.

Method of obtaining 4- (dimethylamino) -1-alkyl -1-methyl-2-butyn-1-ols . RF Patent No. 2378249. 2010, Blue. No. 1. / S Dzhemilev U.M., Shaibakova M.G., Titova I.G., Makhmudiyarov G.A., Ramazanov I.R., Ibragimov A.G./.