Amino alcohols, compounds featuring both amino (-NH₂) and hydroxyl (-OH) functional groups, play a crucial role in modern organic chemistry due to their bifunctional nature, enabling applications in asymmetric synthesis, catalysis, and the production of biologically active substances. This review explores various synthesis methods, including epoxide ring-opening, reductive amination, and multicomponent reactions, while emphasizing stereochemical control and environmental sustainability. It also examines their reactivity in nucleophilic substitutions, epoxide openings, and Mannich reactions, highlighting their utility as chiral ligands. Drawing from empirical and theoretical studies up to 2025, the analysis evaluates process efficiency and ecological viability, integrating fundamental and practical aspects of organic synthesis. Contemporary applications span pharmaceuticals, materials science, and agrochemistry, with a focus on chiral derivatives and bio-active compounds.

Amino alcohols, synthesis methods, chemical reactivity

Chiral Amino Alcohols via Catalytic Enantioselective Petasis Borono ... (2025). ACS Publications.

Karimov, J.S. (2022). Synthesis of salicylic acid compounds containing thiourea fragment. American Journal of Social and Humanitarian Research, 3(11), 421-427.

Niyazov, L.N., Brel, A.K., Bakhromov, H.K., Gapurov, U.U., & Karimov, J.S. (2021). Synthesis of sodium salt derivative of salicylic acid. Materials of the international scientific-theoretical conference "Kuatbekov Readings-1: Lessons of Independence," dedicated to the 30th anniversary of the Independence of the Republic of Kazakhstan.

Stereoselective amino alcohol synthesis via chemoselective ... (2025). PubMed.

Karimov, J.S. (2021). Niyazov Laziz Nurkhonovich. Thiourea derivatives with hydroxybenzoic acids. Universum: Chemistry and Biology, 2021, No. 8(86). URL: https://cyberleninka.ru/article/n/proizvodnye-tiomocheviny-s-gidroksibenzoyny.

Karimov, J.S. & Djunaidov, X.H. (2022). Analysis of synthesis of salicylic acid compounds containing thiourea fragment. In Chemistry and Medicine: From Theory to Practice (pp. 183-184).

Sobirzoda, K.J. (2022). Mechanism of synthesis reaction of 4-N diethyl amino butyn-2 ol-1. European Journal of Innovations in Nonformal Education, 2(3), 61-67.

Smith, J. et al. (2024). Carborane-Catalyzed Aromatic Halogenation: Green Approaches. Current Opinion in Green and Sustainable Chemistry, 45, 100–115.

Karimov Javoxir Sobirzoda, & Niyazov Laziz Nurxonovich (2021). Thiourea derivatives with hydroxybenzoic acids. Universum: Chemistry and Biology, (8(86)), 61-63.

Karimov, J.S. (2023). Determination of toxicity of (2S)-2-amino-3-(1H-indol-3-yl). Scientific Impulse, 1, 9.

New Approach Facilitates Chiral Amino Alcohol Synthesis (2023). Westlake University.