The rapid expansion of global infrastructure has intensified the need to integrate sustainability principles with advanced safety standards to ensure long-term resilience, environmental protection, and human well-being. This paper develops a comprehensive conceptual framework that aligns sustainable construction methodologies with modern safety engineering systems for resilient infrastructure development. Drawing upon interdisciplinary literature in environmental science, construction engineering, renewable energy safety, and computational forecasting models, the study synthesizes existing knowledge to identify systemic gaps in current infrastructure practices. Particular attention is given to material sustainability, emissions reduction, occupational safety, and lifecycle environmental impacts, as reflected in studies on construction waste recycling and industrial emissions management (de Andrade Salgado F, de Andrade Silva F, 2022; Ahmed Ali K et al., 2020). The framework integrates environmental risk assessment, circular construction principles, and safety compliance mechanisms into a unified model for infrastructure planning and execution. The study further explores the intersection of emerging technologies, such as machine learning-based predictive systems, and their role in improving safety and sustainability outcomes (Ajiga et al., 2024). Findings suggest that fragmented regulatory systems and inconsistent sustainability practices remain key barriers to infrastructure resilience. The proposed framework offers a structured pathway for harmonizing environmental sustainability with engineering safety standards, contributing to policy advancement and practical implementation in global construction systems.