International Journal of Medical Sciences And Clinical Research

Integrated Multidisciplinary and Intelligent Decision Support for Complex Chronic Care: A Comparative Review of Allergic Rhinitis–Asthma Comorbidity and Contemporary Oncology Practice

Dr. Amelia Sørensen — Wed, 01 Apr 2026 00:00:00 +0000

Background: Contemporary clinical care increasingly confronts diseases that are biologically complex, clinically heterogeneous, and operationally demanding. Two areas exemplify this challenge in particularly distinct yet conceptually related ways: allergic rhinitis with comorbid asthma, and cancer management through multidisciplinary tumor boards. The literature on allergic airway disease shows that rhinitis and asthma are strongly interconnected at epidemiological, immunological, symptomatic, and quality-of-life levels, requiring coordinated diagnostic and therapeutic approaches (Leynaert et al., 2000; Kalpaklioğlu & Baççioğlu, 2008; Bousquet et al., 2020; GINA, 2023). Meanwhile, oncology literature demonstrates that multidisciplinary decision-making has become central to patient-centered, precision-oriented management, with recent studies exploring the role of artificial intelligence and large language models as adjunctive tools in tumor boards and cancer care (Luchini et al., 2020; Benary et al., 2023; Sorin et al., 2023; Uprety et al., 2023).

Objective: This article develops an integrative review of how multidisciplinary practice, decision support, and patient-centered outcome assessment can improve management in two major clinical domains: allergic rhinitis–asthma comorbidity and oncology. It also critically evaluates the emerging role of artificial intelligence-based systems in complex clinical decision environments.

Methodology: A qualitative integrative review was conducted strictly on the basis of the references supplied. The study synthesized literature across epidemiology, pathophysiology, guideline-based care, quality of life, environmental and genetic risk, tumor board practice, Bayesian and AI-assisted decision systems, and large language model applications in healthcare.

Results: The review identifies four major findings. First, allergic rhinitis and asthma should be approached as linked airway disorders requiring coordinated evaluation. Second, disease burden extends beyond symptoms to productivity, function, psychosocial well-being, and treatment complexity. Third, multidisciplinary structures improve decision quality in oncology and provide a transferable model for other complex conditions. Fourth, artificial intelligence and large language models show promise as support tools, but their use remains constrained by concerns around reliability, contextual reasoning, bias, and governance.

Conclusion: The future of complex chronic care lies in combining evidence-based guidelines, multidisciplinary collaboration, nuanced phenotyping, and carefully governed intelligent decision support. The clinical promise of such integration is substantial, but it must remain grounded in human oversight, patient context, and rigorous validation.

Determination of The Antiradical Properties of Quince Seeds Using the DPPH Method

Fri, 10 Apr 2026 00:00:00 +0000

This article is dedicated to the comprehensive evaluation of the antioxidant properties of quince seeds and the determination of their antiradical capacity through the application of the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Within the scope of this study, the primary active components contained within quince seeds, specifically phytochemical compounds and natural antioxidants, have been thoroughly examined. The antioxidant characteristics of the seeds were quantitatively assessed using the DPPH assay. The experimental findings clearly demonstrate that quince seeds possess a high level of antiradical activity. Furthermore, the results indicate that these seeds hold significant potential as a natural source of antioxidants, offering substantial benefits for human health and pharmacological applications.

Acute Chronic Glomerulonephritis in Age-Related Performance

Rakhimova Shakhzoda Avazovna, Suyunov Og’abek Oybek o’g’li — Thu, 09 Apr 2026 00:00:00 +0000

This article examines the clinical, pathogenetic, and morphofunctional characteristics of acute and chronic glomerulonephritis in age-related contexts, focusing on differences in onset, course, immune-inflammatory activity, and the risk of renal dysfunction progression.

Clinical Efficacy of The Postbiotic Drug Biodonatum In Children with Pneumonia and Reduced Sensitivity to Antibiotic Therapy

Kholtaeva F.F., Zoirova A.T. — Fri, 10 Apr 2026 00:00:00 +0000

Community-acquired pneumonia remains one of the leading causes of morbidity and mortality in the pediatric population worldwide, with antimicrobial resistance constituting a mounting threat to successful clinical management. The emergence and rapid dissemination of antibiotic-resistant bacterial strains have substantially reduced the therapeutic arsenal available to clinicians treating childhood pneumonia, necessitating the investigation of adjunctive treatment strategies capable of enhancing clinical recovery and restoring microbial equilibrium. This study aimed to evaluate the clinical efficacy, safety profile, and microbiome-modulating effects of the postbiotic preparation Biodonatum when administered as an adjunct to standard antibiotic therapy in children diagnosed with community-acquired pneumonia and demonstrating reduced sensitivity to first-line antibiotic agents. A prospective, randomized, controlled clinical trial was conducted at the Department of Pediatric Infectious Diseases, Tashkent State Medical University, enrolling 90 children aged 3 to 14 years with confirmed pneumonia and documented reduced antibiotic susceptibility. Participants were randomized into two equal groups: the intervention group (n = 45) received standard antibiotic therapy supplemented with Biodonatum, while the control group (n = 45) received standard antibiotic therapy alone. Clinical, laboratory, and microbiological parameters were assessed at baseline and on days 7 and 14 of treatment.