https://theusajournals.com/index.php/ijmscr <p><strong>International Journal of Medical Sciences And Clinical Research (2771-2265)</strong></p> <p><strong>Open Access International Journal</strong></p> <p><strong>Last Submission:- 25th of Every Month</strong></p> <p><strong>Frequency: 12 Issues per Year (Monthly)</strong></p> Oscar Publishing Services en-US International Journal of Medical Sciences And Clinical Research 2771-2265 https://theusajournals.com/index.php/ijmscr/article/view/5382 <p>Celiac disease (CD) is a chronic autoimmune enteropathy triggered by gluten ingestion in genetically predisposed individuals. While the classic presentation involves intestinal damage, a subset of children presents with positive celiac-specific antibodies, particularly against tissue transglutaminase (tTG), but have normal or near-normal duodenal villous architecture upon biopsy. This condition is often referred to as potential celiac disease (PCD). Understanding the natural history and factors influencing the progression from PCD to overt CD (characterized by mucosal atrophy) is crucial for clinical management. This article synthesizes findings from recent studies to explore the progression of CD in children with positive tTG antibodies and initially normal duodenal architecture. It examines factors associated with progression, potential biomarkers, and current diagnostic and management approaches for this specific pediatric population.</p> Marcio Fleites Rico Linan Copyright (c) 2025 Marcio Fleites , Rico Linan https://creativecommons.org/licenses/by/4.0 2025-05-01 2025-05-01 5 05 1 5 https://theusajournals.com/index.php/ijmscr/article/view/5484 <p>Meibomian gland dysfunction (MGD) is considered a key pathogenic factor in the development of dry eye syndrome (DES). The aim of this study was to assess the anatomical and functional state of the meibomian glands in military personnel with symptoms of DES using the LacryDiag diagnostic system. Materials and Methods. A total of 120 military personnel (240 eyes) with complaints of DES symptoms were examined. Two control groups were formed: individuals with DES symptoms not serving in the military (n=40), and healthy participants (n=40). The study utilized meibography methods, visualization with LacryDiag, and calculation of the meibomian gland dysfunction index (MGDI). Gland density analysis was performed using the ImageJ software. Results. In the group of military personnel, the average meibomian gland density was 28.6%, corresponding to moderate atrophy. In control group 1, the value reached 51.4%, and in control group 2 — over 70%. The average MGDI value in the main group was 1.58±0.34 points, compared to 1.22±0.22 and 0.48±0.11 in the respective control groups (p&lt;0.05). A strong positive correlation was established between the OSDI index and MGDI in military personnel (r=0.701). Conclusion. Military personnel demonstrate more pronounced meibomian gland dysfunction than civilian individuals, which confirms the need for in-depth diagnosis and prevention of DES using high-precision methods such as LacryDiag.</p> Abdullaev Sh.R. Mamatov J.F. Copyright (c) 2025 Abdullaev Sh.R., Mamatov J.F. https://creativecommons.org/licenses/by/4.0 2025-05-08 2025-05-08 5 05 6 10 10.37547/ijmscr/Volume05Issue05-02