American Journal Of Biomedical Science & Pharmaceutical Innovation

EXPLORING NEW PATHWAYS: PROCESS DEVELOPMENT FOR CEFETAMET SODIUM SYNTHESI

Ritesh Kumar Jat — 2024-11-01

Cefetamet Sodium, a third-generation cephalosporin antibiotic, has gained significant attention due to its efficacy against a broad spectrum of bacterial infections. However, existing synthesis methods often present challenges such as low yields, complex procedures, and environmental concerns. This study presents a comprehensive approach to process development aimed at optimizing the synthesis of Cefetamet Sodium. We explored novel pathways, employing innovative synthetic routes and green chemistry principles to enhance yield and reduce waste. Key parameters including reaction conditions, catalyst selection, and purification techniques were systematically evaluated to establish an efficient and reproducible process. The results demonstrated significant improvements in overall yield and purity of the final product. Additionally, the developed process was assessed for scalability, feasibility, and economic viability. This research contributes valuable insights into the synthesis of Cefetamet Sodium, paving the way for more sustainable production practices in the pharmaceutical industry.

EXPLORING THE PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF HYPTIS SUAVEOLENS L. IN EXPERIMENTAL MODELS

Dharmendra Panwar — 2024-11-02

Hyptis suaveolens L. (Lamiaceae), commonly known as "shrubby mint," is a medicinal plant traditionally used for its anti-inflammatory, antimicrobial, and antioxidant properties. This study aims to explore the phytochemical composition and pharmacological effects of Hyptis suaveolens in animal models. Phytochemical analysis was conducted to identify bioactive compounds present in the plant, using techniques such as gas chromatography-mass spectrometry (GC-MS) and thin-layer chromatography (TLC). The pharmacological evaluation involved in vivo testing for anti-inflammatory, analgesic, antipyretic, and antimicrobial activities. The results revealed the presence of essential oils, flavonoids, alkaloids, and terpenoids, which contributed to the observed pharmacological effects. In animal models, Hyptis suaveolens exhibited significant anti-inflammatory and analgesic effects, corroborating its traditional use in folk medicine. These findings provide valuable insights into the therapeutic potential of Hyptis suaveolens, supporting further clinical studies to confirm its efficacy and safety for medicinal use.

PREPARATION OF THERMOCHEMICALLY ACTIVATED CARBON ADSORBENTS BASED ON COTTON STEM AND COTTON SHELL AND THEIR IR SPECTROSCOPY ANALYSIS

Qo’chqarova Durdona Ilxomjon qizi — 2024-11-08

This article discusses the practical importance of adsorbents today, areas of application, and methods of obtaining activated carbon adsorbents based on local raw materials. Preparation of adsorbents activated by the method of thermochemical activation based on cotton stalks and cotton bolls, functional groups in the obtained adsorbents were analyzed by IR spectroscopy.