https://theusajournals.com/index.php/ajbspi/issue/feed American Journal Of Biomedical Science & Pharmaceutical Innovation 2025-07-17T07:45:25+00:00 Oscar Publishing Services info@theusajournals.com Open Journal Systems <p><strong>American Journal Of Biomedical Science &amp; Pharmaceutical Innovation (<span class="ng-scope"><span class="ng-binding ng-scope">2771-2753</span></span>)</strong></p> <p><strong>Open Access International Journal</strong></p> <p><strong>Last Submission:- 25th of Every Month</strong></p> <p><strong>Frequency: 12 Issues per Year (Monthly)</strong></p> <p> </p> https://theusajournals.com/index.php/ajbspi/article/view/6361 Computational Modeling of Skin Behavior and Neo-tissue Formation in Post-Mastectomy Breast Reconstruction with Tissue Expansion 2025-07-01T00:53:44+00:00 Dr. Helena M. Weiss helena@theusajournals.com <p>Post-mastectomy breast reconstruction using tissue expanders is a widely adopted technique that relies on controlled mechanical stretching of skin and soft tissues to facilitate neo-tissue formation. This study presents a computational modeling framework to simulate skin behavior and tissue growth during the expansion process. Utilizing a finite element approach combined with growth algorithms, the model accounts for the skin’s nonlinear anisotropic properties, mechanical adaptation, and the biological response of surrounding tissues. The simulation results demonstrate key insights into stress distribution, tissue strain patterns, and rates of neo-tissue generation, which closely align with observed clinical outcomes. By validating the model against empirical data, the study offers predictive capabilities for optimizing expander design, placement, and inflation protocols. This computational strategy not only enhances the understanding of tissue mechanics in reconstructive surgery but also supports personalized surgical planning for improved aesthetic and functional results.</p> 2025-07-01T00:00:00+00:00 Copyright (c) 2025 Dr. Helena M. Weiss https://theusajournals.com/index.php/ajbspi/article/view/6470 Advances in Parasitology and Helminthology: Current Trends and Challenges 2025-07-15T04:48:10+00:00 Ubbiniyazova Jamila Komekbaevna ubbiniyazova@theusajournals.com <p>The article examines that parasitology and helminthology are rapidly evolving fields that play a critical role in understanding host-parasite interactions, disease pathogenesis, and the development of diagnostic and therapeutic strategies. This article reviews recent advances in the study of parasitic and helminthic organisms, with a focus on molecular diagnostics, host immune responses, epidemiological trends, and emerging patterns of drug resistance. Particular attention is given to zoonotic helminths and the implications of climate change and globalization on their distribution and transmission dynamics. Furthermore, the integration of omics technologies, such as genomics and proteomics, has significantly enhanced our ability to study parasitic systems at a mechanistic level. This synthesis of current knowledge provides insights into unresolved challenges and highlights potential directions for future research and public health interventions.</p> 2025-07-14T00:00:00+00:00 Copyright (c) 2025 Ubbiniyazova Jamila Komekbaevna https://theusajournals.com/index.php/ajbspi/article/view/6486 Study of The Effect of Polyphenol Plantagin On Calcium Transport in The Presence of NMDA Receptor Agonists and Antagonists 2025-07-17T07:45:25+00:00 Mamadaminov Rakhmatjon Rakhimjon oglu mamadaminov@theusajournals.com Khoshimov Nozimjon Numonjonovich khoshimov@theusajournals.com <p>This study investigated the effect of Plantagin polyphenol on NMDA receptor binding sites using glycine, Mg2+ and Zn2+ ions. A suspension of rat brain synaptosomes was isolated by differential centrifugation. Changes [Ca2+]in concentration in the suspension medium of rat brain synaptosomes were measured using the fluorescent probe Fluo-4 AM. It was noted that synaptosomal Ca2+ transport remained virtually unchanged under the influence of plantago polyphenols in Zn2+ and Mg2+ in rat brain synaptosomal suspensions incubated with L-glutamate-Fluo-4 AM. The polyphenol Plantagin competes with glycine for binding to the glycine site of NMDA receptors, reducing the likelihood of full receptor activation even in the presence of glutamate, which leads to a limitation of Ca²⁺ influx, and therefore plays an important role in preventing excitotoxicity.</p> 2025-07-16T00:00:00+00:00 Copyright (c) 2025 Mamadaminov Rakhmatjon Rakhimjon oglu, Khoshimov Nozimjon Numonjonovich