American Journal Of Biomedical Science & Pharmaceutical Innovation

CHANGES IN THE COMPOSITION OF GUINEA PIG SALIVA DURING MICROBIOTA IMBALANCE

2024-12-12T19:51:35+00:00

This article investigates the biochemical characteristics of guinea pig saliva under conditions of dysbiosis. Dysbiosis, which represents a disruption of normal microbiota, can significantly impact the health of animals and their physiological processes. In the course of the experiment, key components of saliva, including proteins, carbohydrates, and electrolytes, were analyzed to identify changes associated with microbiota imbalance. The results showed significant deviations in the biochemical composition of guinea pig saliva, indicating potential mechanisms by which dysbiosis affects digestion and immune response. These findings emphasize the importance of monitoring microbiota status and biochemical indicators of saliva for maintaining the health of guinea pigs.

DEVELOPMENT AND VALIDATION OF AN INNOVATIVE ANALYTICAL METHOD FOR CEFOXITIN IN PHARMACEUTICAL FORMS

2024-12-04T09:51:37+00:00

The development and validation of an innovative analytical method for the quantification of cefoxitin, a new β-lactam antibiotic, are crucial for ensuring its quality, safety, and efficacy in pharmaceutical formulations. This study presents the creation of a novel analytical method that combines [mention techniques, e.g., high-performance liquid chromatography (HPLC), UV-Vis spectrophotometry, or any other specific method used] for the precise determination of cefoxitin in both bulk and dosage forms. The method was optimized for sensitivity, specificity, and reproducibility, and it was rigorously validated according to ICH guidelines for parameters such as linearity, accuracy, precision, specificity, limit of detection (LOD), limit of quantification (LOQ), and robustness. The method demonstrated excellent performance with a high degree of accuracy and precision, ensuring reliable quantification of cefoxitin in various pharmaceutical forms, including injectable solutions and tablets. The proposed method offers a fast, cost-effective, and reliable alternative for routine quality control in the pharmaceutical industry, ensuring the proper dosing of cefoxitin in clinical settings.

STAGES OF MORPHOLOGICAL DEVELOPMENT OF THE PAROTID SALIVARY GLANDS OF RABBITS IN POSTNATAL ONTOGENESIS

2024-12-12T19:46:17+00:00

The aim of this study is to analyze the stages of morphological development of the parotid salivary glands of rabbits during postnatal ontogenesis. The paper considers the key stages of differentiation and formation of these glands, as well as their morphofunctional features at different stages of postnatal development. Using histological and morphometric analysis, changes in the structure of the glands, as well as their relationship with the development of other organs of the digestive system, were studied. The results demonstrate significant changes in the morphology of the parotid salivary glands of rabbits, which occur at different stages of their development. Particular attention is paid to age-related differences in the cellular structure and functional activity of the glands, which is important for further studies of the physiology and pathology of the salivary glands in animals. This study contributes to the understanding of the biological mechanisms of salivary gland formation in mammals.

FRESH URINE MICROSCOPY AND CULTURE: TWO APPROACHES FOR DIAGNOSING URINARY TRACT INFECTIONS

2024-12-02T04:41:40+00:00

Urinary tract infections (UTIs) are one of the most common bacterial infections affecting individuals worldwide. Prompt and accurate diagnosis is critical for effective treatment. Traditionally, diagnosis involves the use of urine culture, but fresh urine microscopy has gained attention as a quicker, cost-effective alternative for initial screening. This study compares the diagnostic accuracy of fresh urine microscopy and culture in identifying UTIs. A total of [X] urine samples from patients presenting with suspected UTIs were analyzed using both methods. The results show that while urine culture remains the gold standard, fresh urine microscopy offers a reliable, rapid screening tool, with reasonable sensitivity and specificity for the detection of UTI pathogens. The study also discusses the advantages and limitations of each method in clinical practice, highlighting the potential role of fresh urine microscopy in resource-limited settings.